If you opt out, though, you may still receive generic advertising.Īlso, if you opt out of online behavioral advertising, you may still see ads when you sign in to your account, for example through Online Banking or MyMerrill. If you prefer that we not use this information, you can opt out of online behavioral advertising. This information may be used to deliver advertising on our Sites and offline (for example, by phone, email and direct mail) that's customized to meet specific interests you may have. Here's how it works: We gather information about your online activities, such as the searches you conduct on our Sites and the pages you visit. Relationship-based ads and online behavioral advertising help us do that. We strive to provide you with information about products and services you might find interesting and useful. Statistics and metrics included in our ESG documents are estimates and may be based on assumptions or developing standards. are registered as futures commission merchants with the CFTC and are members of the NFA.Ĭompany goals are aspirational and not guarantees or promises that all goals will be met. BofA Securities, Inc., Merrill Lynch, Pierce, Fenner & Smith Incorporated and Merrill Lynch Professional Clearing Corp. Securities, strategic advisory, and other investment banking activities are performed globally by investment banking affiliates of Bank of America Corporation ("Investment Banking Affiliates"), including, in the United States, BofA Securities, Inc., Merrill Lynch, Pierce, Fenner & Smith Incorporated, and Merrill Lynch Professional Clearing Corp., all of which are registered broker-dealers and Members of SIPC, and, in other jurisdictions, by locally registered entities. Lending, derivatives, and other commercial banking activities are performed globally by banking affiliates of Bank of America Corporation, including Bank of America, N.A., Member FDIC. "Bank of America" is the marketing name for the global banking and global markets business of Bank of America Corporation. Investment products offered through MLPF&S and insurance and annuity products offered through MLLA:Īre Not Insured by Any Governmental AgencyĪre Not a Condition to Any Banking Service or Activity (“MLLA”), a licensed insurance agency and wholly-owned subsidiary of BofA Corp. Insurance and annuity products are offered through Merrill Lynch Life Agency Inc. Trust and fiduciary services are provided by Bank of America Private Bank, a division of Bank of America, N.A., Member FDIC, and a wholly-owned subsidiary of Bank of America Corporation (“BofA Corp.”). MLPF&S is a registered broker-dealer, registered investment adviser, Member SIPC and a wholly owned subsidiary of BofA Corp. Merrill Lynch, Pierce, Fenner & Smith Incorporated (also referred to as “MLPF&S” or “Merrill”) makes available certain investment products sponsored, managed, distributed or provided by companies that are affiliates of Bank of America Corporation (“BofA Corp.”). When you visit these sites, you are agreeing to all of their terms of use, including their privacy and security policies. Bank of America has not been involved in the preparation of the content supplied at the unaffiliated sites and does not guarantee or assume any responsibility for its content. Certain links may direct you away from Bank of America to an unaffiliated site. Bank of America does not assume liability for any loss or damage resulting from anyone's reliance on the information provided. These materials are for informational purposes only. Opinions or ideas expressed are not necessarily those of Bank of America nor do they reflect their views or endorsement. Any opinions expressed herein are given in good faith, are subject to change without notice, and are only correct as of the stated date of their issue.Ĭontent contained herein may have been produced by an outside party that is not affiliated with Bank of America or any of its affiliates (Bank of America). Before acting on any information in this material, you should consider whether it is suitable for your particular circumstances and, if necessary, seek professional advice. This material does not take into account your particular investment objectives, financial situations or needs and is not intended as a recommendation, offer or solicitation for the purchase or sale of any security, financial instrument, or strategy. Investing in securities involves risks, and there is always the potential of losing money when you invest in securities.
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These examples are programmatically compiled from various online sources to illustrate current usage of the word 'gruesome.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. 2023 On Thursday, the streamer announced the premiere date for its own adaptation of the same gruesome story, complete with a different cast and crew. Michael O'sullivan, Washington Post, 23 Feb. 2023 Other miscellaneous characters pop up here and there as bear fodder, including paramedics responding to attacks and teenage punks, most of whom die gruesome deaths. 2023 An Indiana man was taken into custody last week in connection with a gruesome cold case murder i Georgia that had been unsolved for more than three decades, authorities said. 2023 But a year after this once-bucolic suburb of Kyiv became a watchword for gruesome wartime atrocities, scars remain, and the path toward achieving any kind of accountability, even years from now, remains strewn with obstacles. Quinci Legardye, Harper's BAZAAR, 25 Mar. 2023 Just because baby eating is off the table, that doesn't mean baby sacrifice or something just as gruesome could happen. A consequence, especially of a disaster or misfortune: famine as an aftermath of drought. Samantha Olson, Seventeen, But Warren provided gruesome details about the kids' death that were far more graphic than Rexburg (Idaho) Police Det. aftermath synonyms, aftermath pronunciation, aftermath translation, English dictionary definition of aftermath. Jackie Strause, The Hollywood Reporter, Now, the gruesome murder - which Candy, her lawyer, and psychiatrists have claimed was self-defense - is the subject of HBO Max's true crime series Love and Death, starring Elizabeth Olsen, Jesse Plemons, Lily Rabe, and Patrick Fugit. Recent Examples on the Web The fourth and fifth episodes delve into that sentiment by showing pieces of Betty’s gruesome death from the perspective of Candy, sourced from Candy’s testimony during the trial. Free online pdf signer reddit update#īut with it's recent update it now requires an additional e-sign subscription (in addition to the subscription for Foxit editor that I am already paying for) to simply place my ink signature on documents. So I figured it's finally time to find a better solution. I want an easy solution where I can: (i) fill out forms, and either (ii) electronically sign them, or (iii) place a jpg image of an ink signature on the document. Use a save the cat pdf reddit 0 template to make your document workflow more streamlined. Regarding (iii), ideally the program allows me to store my ink signature so that I can easily place it on different documents. The way to create an electronic signature for a PDF online. I am happy to pay some small cash for the software (about 10$ per year), but aren't willing to shell out the 100+ dollars that Adobe and Foxit are charging for it. We study mental health discourse on the popular social media:reddit. Are there any better options?ĮDIT: Thanks everyone for the ideas. Answer all questions on the recertification application, if you can. Seeking and sharing practices in online forums, and social media like Twitter. You must at least provide your name, address, and signature to begin your recertification. Personally, I don't feel super comfortable uploading private documents to some website, so I am skipping the online options like smallpdf & co. HiPDF will quickly and stably upload the file. I love the idea of free & open source, so I will give Okular a try first. Then create electronic signature by typing, drawing or uploading. Place signature in the document as you need. Finally click on download to get signed PDF document. In case the pressure goes up from 0.1 MPa to 200 MPa, the viscosity can rise to 3 to 7 times the original value. For comparison: This same change in viscosity is usually provoked by a minor temperature change of 1 K (1 ☌). Most liquids react to a significantly altered pressure (from 0.1 MPa to 30 MPa) with a viscosity change of about 10 %. However, fluids are not dramatically affected if the applied pressure is low or medium: liquids are almost non-compressible in this pressure range. Normally, an increase in pressure causes a fluid’s viscosity to increase, too. Three factors determine a substance’s flow behavior. Still, shear rate is not the only influencer. To learn more consult “ The Rheology Handbook”. The flow behavior of non-Newtonian liquids can be far more complex than these basic examples. yogurt), while for others the viscosity increases with increasing shear rate (curve 3 | e.g. If its viscosity changes with the shear rate, a liquid is non-Newtonian and – for exact definition – one has to specify the apparent viscosity.ĭifferent shear-dependent fluids behave differently: For some, their viscosity decreases when the shear rate increases (curve 2 | e.g. Typical Newtonian liquids are water or salad oil. For a Newtonian liquid, this function is a straight line (curve 1) see figure 6. Such fluids are named ‘Newtonian liquids’ after Sir Isaac Newton.Ī viscosity function shows the viscosity over the shear rate. the shear rate – acting upon the fluid, it is ideally viscous. If a fluid’s internal flow resistance is independent of the external force – i.e. High-viscosity fluids resist deformation. Fluids which flow easily show a low resistance to deformation. viscous fluids that contain an elastic portion. The specific field of viscometry covers ideally viscous fluids, and – considering certain restrictions – also viscoelastic liquids, i.e. sweet jelly) or as a viscoelastic liquid (like e.g. According to a material’s properties, we either classify it as a viscoelastic solid (like e.g. That is, substances which are neither completely elastic, nor entirely viscous. In everyday life, we mostly come across viscoelastic materials. Scientists specify solid materials as being elastic and liquids as being viscous. Imagine all materials as classified on a virtual scale from solid to liquid. Rheology deals with the flow behavior and deformation of materials. In order to determine a fluid’s viscosity, you have to enter the field of viscometry, a subject area of a wider science called rheology. My husband and I are YouTubers who like to put out a professional product but don't yet have money in the budget for a professional movie editing program. Thank you for listening.Īmazing what you can do with this free product! I also went through some struggle just importing my video into the editing section. I can select specific parts of clips on iPad, just on here it is much more confusing. I have done this on iPad and it works just fine. I tried to select a specific part of my clip I imported, and instead I had to split the clip, since I went through this struggle. I also do thinkit is a bit confusing to use on a laptop or any computer in general. Once it almost took 30 minutes, I'm not sure if this is something to do with the space on your computer, but this is defintely a big flaw I deal with when I try to download it on several devices. I love iMovie and I dont know if this is just for me, but it takes very long to download. When I started to use iMovie I did realize it is really good quality. iMovie works great for editing and organizing videos and pictures. I am gonna startwith the pros, than Iwil get to the cons. System Requirements: macOS 12.6 or later, 4GB RAM, 3.6GB of available disk space. * Export finished videos using the App Preview share option * Highlight features with 11 animated titles designed to showcase apps in action * Import iPhone and iPad screen recording videos captured with QuickTime Player * Export a video optimized for YouTube, Facebook, and other popular video destinations * Email videos with Mail Drop when signed in to iCloud * Send your project to Final Cut Pro and take advantage of advanced editing tools, professional effects, third-party plug-ins, and more * Choose from 48 fun video and audio effects * Automatically zoom in on faces and glide across panorama photos with the Ken Burns Effect * Stabilize shaky video for a smoother picture that's easier to watch * Give your video a boost with easy-to-use color controls * Instantly improve the look and sound of your video using one-click Enhance * Create a soundtrack using built-in music and sound effects, songs from your iTunes library, songs you've recorded in GarageBand, and your own narration * Create sophisticated picture-in-picture, side-by-side, and green screen effects * Speed up and slow down the action with fast-forward and slow-motion effects * Enhance your movie by adding titles, transitions, and 3D globes and travel maps * Import Magic Movie, Storyboard and Movie projects created with iMovie on iPhone or iPad into the timeline * Support for 1080p HD video at 60 frames per second for smoother, more lifelike action shots * Change focus points or the depth effect for video shot in Cinematic mode on iPhone 13 or later (requires macOS Monterey or later) * Edit movies at up to 4K resolution with video from iPhone 6s or later, GoPro, and other Ultra HD cameras on compatible Macs * Select the best videos and photos for your trailer with the help of animated drop zones * Customize movie studio logos, cast names, and credits * Choose from 29 trailer templates with stunning graphics and original scores by some of the world's top film composers * Background import lets you begin watching and sharing video instantly * Quickly share a clip or a portion of a clip * See all your video clips and photos organized in one place You can even start editing movies on an iPhone or iPad, and finish them on a Mac. Browse your video library, share favorite moments, and create beautiful movies that you can edit at resolutions up to 4K. With a streamlined design and intuitive editing features, iMovie lets you create Hollywood-style trailers and beautiful movies like never before. If you’re looking for a more eco-friendly Kindle case, this one is made with cork - a material that is renewable and biodegradable - and 28% recycled post-consumer plastic. Compatibility: 11 th generation and Signature Edition.They come in neutral colors, vibrant shades, and a variety of patterns to suit just about any taste. With that in mind, browse the best Kindle Paperwhite cases for 10th and 11th generation models. There are also other features to consider, too, like an elastic hand strap or a cover that folds behind your Kindle for easier reading. And while many Kindle Paperwhite models are water-resistant, look for a water-safe or waterproof case if you’d like extra protection when reading by the pool or at the beach. If you have a Kindle Paperwhite Signature Edition that’s capable of wireless charging, you may want a case that’s compatible with your wireless charging dock. Many are also designed with cable cutouts to allow for easy charging. Other popular options include water-safe fabric, genuine leather, or cork covers.Īs for functionality, most cases will wake your Kindle when opened and put it to sleep when closed. Many Kindle cases are made from vegan leather, which is usually affordable, lightweight, and water-safe or waterproof. Whether you want a basic case or a more decorative option (like one that makes your Kindle look like a vintage book) there are several different materials to choose from. Some cases even have a built-in kickstand so you can use your Kindle hands-free. Luckily, the best Kindle Paperwhite cases are sized to perfectly fit your e-reader model, made from durable materials, and feature designs that are so you. After you’ve pulled your brand new Kindle out of the box, it’s time to outfit it with a protective case. Since 1975, the San Francisco Mint has been used almost exclusively for proof coinage, with the exception of the Susan B. In 1968, this facility took over most proof coinage production from the Philadelphia Mint, but continued striking a supplemental circulating coinage from 1968 through 1974. Beginning in 1955, circulating coinage from San Francisco was suspended for 13 years. There are plans for adaptive reuse, including as a museum, and continued special events space. Now known as the Old San Francisco Mint, it was designated as a National Historic Landmark in 1961 and sold to the city of San Francisco in 2003. The mint resumed operation soon thereafter, continuing until 1937 at this site. Leach, and his men preserved the building and the bullion that backed the nation's currency. Efforts by Superintendent of the Mint, Frank A. At the time of the 1906, the Mint held $300 million, fully a third of the United States' gold reserves. The building is based on a concrete and granite foundation, designed to thwart tunneling into its vaults. These features saved it during the fire of 1906 that followed the San Francisco Earthquake, when the heat melted the plate glass windows and exploded sandstone and granite blocks with which it was faced. The building had a central pedimented portico flanked by projecting wings in an E-shape it was built around a completely enclosed central courtyard that contained a well. It was quarried at Newcastle Island, British Columbia, near the city of Nanaimo and imported for this purpose. The columns and most of the exterior and upper floors was constructed of sandstone. Mullett in a conservative Greek Revival style with a sober Doric order. The second US Mint building here, completed in 1874 for the Department of the Treasury, was designed by Alfred B. It has grown by 350% since launch and raised $10M from East West Bank. The company was founded in 2020 and is headquartered in San Jose, California, USA with offices in Shanghai, China, Bangalore, India and the Philippines. Kami Vision software powers 15 million devices, serving 6 million active users in 120 countries and holds over 100 patents. Kami Vision’s solutions include KamiCare, a fall management solution for memory care and senior living communities and the Kami IoT solution for resellers of camera-based smart home products. Kami’s open AI platform enables easy implementation and scaling of affordable, highly accurate edge AI software solutions for a range of use cases and industries. Kami Vision is an artificial intelligence (AI) services company focused on security and safety solutions that improve the quality of life for people around the world. "The new Smart Detect features underscore our mission to develop AI solutions that improve security, safety and peace of mind for people and businesses around the world," added Durrani. By distinguishing between people, vehicles and animals, users can customize and prioritize the alerts they want to receive and significantly reduce false alarms. Users choose which categories they want to be alerted about and receive detailed identifying information in their Kami Home mobile application. "Users can now receive only the alerts that really matter – someone visiting their home, a pet doing something funny or in need of help – rather than the potential distraction of alerts due to bugs flying in front of the camera or sprinkler heads watering the lawn."Īvailable in any Kami Home smart security camera, the Smart Detect AI models accurately identify the characteristics of any person, vehicle or animal. "Our new Smart Detect AI models go far beyond the industry standard of motion detection," said Yamin Durrani, CEO of Kami Vision. Kami Home smart security camera's use Smart Detect AI to accurately identify the characteristics of any person, vehicle or animal. One comparison not to make is to Alfred Hitchcock's heights-hating 1958 thriller Vertigo, starring Jimmy Stewart. Possible comparisons for Jason Day's round: Venturi with dehydration, Tiger with torn ACL or, if you want to change sports, Jordan with flu. Just wanted to get it in."Īfter finishing second at the US Open in 20, Day not only has the chance to break through and win a major like fellow Aussie Adam Scott did with the 2013 Masters, but do it in historic fashion, ala Ken Venturi in 1964 at Congressional. I started shaking on 16 tee box and then just tried to get it in, really. The vertigo came back a little bit on the 13th tee box, and then felt nauseous all day. "I felt pretty groggy on the front nine just from the drugs that I had in my system, then kind of flushed that out on the back nine. The 16 Days of Activism against Gender-Based Violence is an annual international campaign that kicks off on 25 November, the International Day for the. Sounds similar to how Day described his Saturday: Some people also feel out of balance when standing or walking. Activities that bring about the signs and symptoms of BPPV can vary from person to person, but are almost always brought on by a change in the position of your head. Episodes of benign paroxysmal positional vertigo can disappear for some time and then recur. The signs and symptoms of BPPV can come and go, with symptoms commonly lasting less than one minute. You can receive effective treatment for benign paroxysmal positional vertigo during a doctor's office visit. Although benign paroxysmal positional vertigo can be a bothersome problem, it's rarely serious except when it increases the chance of falls. This might occur when you tip your head up or down, when you lie down, or when you turn over or sit up in bed. Benign paroxysmal positional vertigo is usually triggered by specific changes in the position of your head. Benign paroxysmal positional vertigo causes brief episodes of mild to intense dizziness. Garner and Affleck, 50, who were married from 2005 to 2015 (finalizing their divorce in 2018), share children Violet, 17, Seraphina, 14, and Samuel, 11.The Gone Girl star continued to celebrate. So what is vertigo, and specifically benign positional vertigo?īenign paroxysmal positional vertigo (BPPV) is one of the most common causes of vertigo - the sudden sensation that you're spinning or that the inside of your head is spinning. So I have no idea what that was, other than I just may have been exhausted.” In one trial, magnesium intake was low in the other, magnesium intake was adequate. I had an MRI on my head and my back and everything came back negative. d) were supplemented with 3 mg/d of boron during two 28-day trials. 12 One possibility is that the global effects of fusion gene expression favor a chromatin conformation in which RUNX1-ETO can bind AsPr and modify its chromatin interactions. RUNX1-ETO alters global chromatin conformation and promoter-enhancer interactions. Questions remain regarding precisely how the RUNX1-ETO fusion protein mediates altered chromatin looping and whether this is an immediate consequence of fusion gene expression or requires previous chromatin remodeling or destabilization. Key findings of these studies are: (1) that PU.1 is regulated by competition between a coding and a noncoding promoter for interaction with the enhancer, (2) that an enhancer-driven lncRNA promotes looping with the sense promoter, and (3) that CBF AMLs can co-opt these 2 mechanisms to reduce PU.1 expression. 12 The fact that PU.1 repression by this mechanism is reversible may be an opportunity for therapeutic targeting. Furthermore, RUNX1-ETO–mediated repression of the PU.1 locus seems to require active maintenance, similar to other reports of RUNX1-ETO–induced chromatin remodeling. Thus, in RUNX1-ETO AML, PU.1 expression is actively repressed by a chromosomal structure that is unfavorable to interaction of the URE with the sense promoter and enhances expression of an antisense transcript that is known to repress PU.1. Knockdown of RUNX1-ETO, which also induces a more mature myeloid phenotype, increases LOUP levels, reduces the PU.1 asRNA:mRNA ratio, and promotes interaction between URE and PrPr (see figure, panel D). Furthermore, RUNX1-ETO also binds to the URE and diminishes LOUP expression. In line with this finding, CBF AMLs have increased AsPr accessibility and asRNA expression compared with AMLs with a normal karyotype. Similar to wild-type RUNX1, the CBF fusion proteins RUNX1-ETO and CBFβ-MYH11 are able to transactivate AsPr, which suggests the intriguing possibility that PU.1 perturbation in CBF leukemias might be mediated by AsPr. Given the known roles of PU.1 and RUNX1 in AML, both studies focused on PU.1 regulation in leukemia. However, the mechanisms of spatiotemporal control of PU.1 expression are not completely resolved. As with the PrPr, AsPr interacts with and is regulated by the URE. PU.1 expression can be negatively regulated by a long noncoding RNA (lncRNA) (PU.1 antisense RNA ), which reduces both PU.1 messenger RNA (mRNA) and the protein and is initiated by an antisense promoter (AsPr) located in exon 3 11 (see figure, panel A). 7 A key PU.1 upstream regulatory element (URE) is located upstream of the sense promoter (proximal promoter ), and this can be positively regulated by RUNX1, which binds directly to the URE 4,8-10 (see figure, panel A). 6 Conversely, reexpression of PU.1 can cause AML cells to differentiate. 4,7 Reduced expression, but not complete ablation, in mice leads to AML. Levels of PU.1 increase during myelopoiesis, 6 but expression is reduced in a range of acute myeloid leukemia (AML) cells, particularly those with core binding factor (CBF) fusions. 3,4 PU.1 does not function as an on/off switch instead, graded expression levels determine its precise role in specific cell types, 5 and expression levels must be tightly controlled throughout development. The transcription factor PU.1 is a master hematopoietic regulator involved in hematopoietic stem cell maintenance and myeloid and B lymphoid lineages. |
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